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Frederick MacKintosh

Abercrombie Professor of Chemical and Biomolecular Engineering

Dr. MacKintosh received his Ph.D. in Theoretical Physics from Princeton University in 1989. Following a postdoctoral fellowship at Exxon Corporate Research, he began his academic career in the University of Michigan’s Physics Department, first as an Assistant and then Associate Professor. In 2001, he joined the Physics faculty of Vrije Universiteit in Amsterdam, as Professor of Theoretical Physics. His key achievements include: the development of commonly used models of elasticity and dynamics of biopolymer gels, combined  experimental and theoretical advances in micro rheology and non-equilibrium, motor-activated gels and active diffusion in cells, as well  as the identification of affine to non-affine transitions and critical behavior in fiber networks.

Dr. MacKintosh’s research focuses on the fundamental material properties of biological and soft matter networks.


Nishi, Kengo; Kilfoil, Maria L; Schmidt, Christoph F; MacKintosh, Fred C; A symmetrical method to obtain shear moduli from microrheology.  arXiv preprint arXiv:1712.07213 2017

Shivers, Jordan; Feng, Jingchen; Sharma, Abhinav; MacKintosh, Fred C; Anomalous normal stress controlled by marginal stability in fiber networks.  arXiv preprint arXiv:1711.00522 2017

Schmidt, Christoph F; Gladrow, Jannes; Fakhri, Nikta; MacKintosh, Fred C; Broedersz, Chase; Broken Detailed Balance of Filament Dynamics in Active Networks..  Bulletin of the American Physical Society, 62 2017

Tang, Zhao; Eichmann, Shannon; MacKintosh, Frederick; Pasquali, Matteo; Brownian diffusion of single walled carbon nanotubes in highly confined rock-like porous media~.  Bulletin of the American Physical Society, 62 2017

Guo, Ming; Pegoraro, Adrian F; Mao, Angelo; Zhou, Enhua H; Arany, Praveen R; Han, Yulong; Burnette, Dylan T; Jensen, Mikkel H; Kasza, Karen E; Moore, Jeffrey R; Cell volume change through water efflux impacts cell stiffness and stem cell fate.  Proceedings of the National Academy of Sciences 2017: 201705179

McCall, Patrick M; MacKintosh, Frederick C; Kovar, David R; Gardel, Margaret L; Cofilin Drives Rapid Turnover and Fluidization of Entangled F-actin.  bioRxiv 2017: 156224

Vorselen, Daan; MacKintosh, Fred C; Roos, Wouter H; Wuite, Gijs JL; Competition between Bending and Internal Pressure Governs the Mechanics of Fluid Nanovesicles.  ACS nano, 11 2017: 2628-2636

Alvarado, Jos¿; Sheinman, Misha; Sharma, Abhinav; MacKintosh, Fred C; Koenderink, Gijsje H; Force percolation of contractile active gels.  Soft Matter, 13 2017: 5624-5644

MacKintosh, Fred; Mechanical critical phenomena and the elastic response of fiber networks.  Bulletin of the American Physical Society, 62 2017

Vahabi, Mahsa; Vos, Bart E; de Cagny, Henri CG; Bonn, Daniel; Koenderink, Gijsje H; MacKintosh, FC; Normal stresses in semiflexible polymer hydrogels.  arXiv preprint arXiv:1712.02733 2017

Vos, Bart E; Liebrand, Luka C; Vahabi, Mahsa; Biebricher, Andreas; Wuite, Gijs JL; Peterman, Erwin JG; Kurniawan, Nicholas A; MacKintosh, Fred C; Koenderink, Gijsje H; Programming the mechanics of cohesive fiber networks by compression.  Soft matter, 13 2017: 8886-8893

Nishi, Kengo; Kilfoil, Maria; Schmidt, Christoph; Mackintosh, Fred; ¿ new method for analyzing high-frequency microrheology data.  Bulletin of the American Physical Society, 62 2017

    • Department of Chemistry
    Email: fcmack@rice.edu