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Gold Nanostar Stability and Use in Complex Matrices



By: Amanda J. Haes
Associate Professor of Chemistry
From: University of Iowa
When: Wednesday, February 22, 2017
4:00 PM - 5:00 PM
Where: Dell Butcher Hall
Abstract: With the growing inclusion and use of nanoparticles in products and devices, developing characterization tools and experimental methods that can be used to predict nanoparticle fate are increasingly important. Two challenges and approaches to better predict structure-function behavior of noble metal nanoparticles will be discussed. First, nanoparticle surface chemistry and shape are often dynamic. Second, the physical stability and properties of nanostructures depend on these same parameters. For instance, when gold nanostars are placed in complex environments, nanoparticle aggregation, ripening, and/or dissolution can occur in often, unexpected ways. In this presentation, the combination of experimental measurements that provide molecular-level insight coupled with semi-empirical modeling will be shown to improve the systematic use of gold nanostars by providing a method for predicting the stability and hence, the fate of nanomaterials in various environmental conditions. After these considerations, localized surface plasmon resonance (LSPR) spectroscopy and surface enhanced Raman scattering (SERS) will be exploited for the direct, qualitative and quantitative detection of small biologically relevant molecules. In the future, these results could be expanded for different nanomaterial shapes, compositions, and molecular targets.